Nuclear magnetic resonance (NMR) is a physical phenomenon in which nuclei in a strong static magnetic field are perturbed by a weak oscillating magnetic field (in the near field and therefore not involving electromagnetic waves) and respond by producing an electromagnetic signal with a frequency characteristic of the magnetic field at the nucleus. This process occurs near resonance, when the oscillation frequency matches the intrinsic frequency of the nuclei, which depends on the strength of the static magnetic field, the chemical environment, and the magnetic properties of the isotope involved; in practical applications with static magnetic fields up to ca. 20 tesla, the frequency is similar to VHF and UHF television broadcasts (60–1000 MHz). NMR results from specific magnetic properties of certain atomic nuclei. Nuclear magnetic resonance spectroscopy is widely used to determine the structure of organic molecules in solution and study molecular physics, crystals as well as non-crystalline materials. NMR is also routinely used in advanced medical imaging techniques, such as in magnetic resonance imaging (MRI).

All isotopes that contain an odd number of protons and/or neutrons (see Isotope) have an intrinsic nuclear magnetic moment and angular momentum, in other words a nonzero nuclear spin, while all nuclides with even numbers of both have a total spin of zero. The most commonly used nuclei are 1
H
 and 13
C
, although isotopes of many other elements (e.g. 2
H
, 6
Li
, 10
B
, 11
B
, 14
N
, 15
N
, 17
O
, 19
F
, 23
Na
, 29
Si
, 31
P
, 35
Cl
, 113
Cd
, 129
Xe
, 195
Pt
) have been studied by high-field NMR spectroscopy as well.

A key feature of NMR is that the resonance frequency of a particular simple substance is usually directly proportional to the strength of the applied magnetic field. It is this feature that is exploited in imaging techniques; if a sample is placed in a non-uniform magnetic field then the resonance frequencies of the sample’s nuclei depend on where in the field they are located. Since the resolution of the imaging technique depends on the magnitude of the magnetic field gradient, many efforts are made to develop increased gradient field strength.

The principle of NMR usually involves three sequential steps:

• The alignment (polarization) of the magnetic nuclear spins in an applied, constant magnetic field B₀.
• The perturbation of this alignment of the nuclear spins by a weak oscillating magnetic field, usually referred to as a radio-frequency (RF) pulse. The oscillation frequency required for significant perturbation is dependent upon the static magnetic field (B₀) and the nuclei of observation.
• The detection of the NMR signal during or after the RF pulse, due to the voltage induced in a detection coil by precession of the nuclear spins around B₀. After a RF pulse, precession usually occurs with the nuclei’s intrinsic Larmor frequency and, in itself, does not involve transitions between spin states or energy levels.

The two magnetic fields are usually chosen to be perpendicular to each other as this maximizes the NMR signal strength. The frequencies of the time-signal response by the total magnetization (M) of the nuclear spins are analyzed in NMR spectroscopy and magnetic resonance imaging. Both use applied magnetic fields (B₀) of great strength, often produced by large currents in superconducting coils, in order to achieve dispersion of response frequencies and of very high homogeneity and stability in order to deliver spectral resolution, the details of which are described by chemical shifts, the Zeeman effect, and Knight shifts (in metals). The information provided by NMR can also be increased using hyperpolarization, and/or using two-dimensional, three-dimensional and higher-dimensional techniques.

NMR phenomena are also utilized in low-field NMR, NMR spectroscopy and MRI in the Earth’s magnetic field (referred to as Earth’s field NMR), and in several types of magnetometers.

https://en.wikipedia.org/wiki/Nuclear_magnetic_resonance